Have you ever caught yourself shouting, "I could just kill this teacher"? What would have to happen to justify such antisocial behavior and weeks of detention? Especially when he is the best teacher you've ever had? Giving you a 5 on a test? Mispronouncing your name during roll call again? How about blowing up the moon and threatening to do the same to Mother Earth—unless you take him out first? And with a cool reward of 100 million from the Defense Department! Okay, now that you're determined... how will you go about it? What does your pathetic class of misfits have in their arsenal to combat Teach's alien technology, strange powers, and tentacles?

The students of Class 3-E are putting an abundance of eggs to good use—aiming for their usual target. Karasuma teaches them the art of parkour while Koro Sensei introduces them to the game of cops and robbers. Then someone gets caught stealing underwear, and of course, Koro Sensei is the prime suspect! But will he be set up... and if so, by whom? Ultimately, the biologically modified Itona discovers that tentacles can sometimes be more of a burden than a gift. He bets everything on his latest assassination attempt on Koro Sensei... but who will save Itona from himself?.