This 8GB RAM is 100% compatible with the Asus MAXIMUS IV EXTREME. What should be considered when upgrading RAM? It is possible to use different RAM sizes in the slots. The fast dual-channel mode is optimally supported when the memory is installed in pairs. When mixing different memory sizes, the dual-channel mode is activated in certain areas. For example, with a configuration of 4GB and 8GB, the Intel Flex technology would activate dual-channel operation for the first 8GB.