The enclosure simply makes an M.2 SSD available as a USB drive. So if the PC can accommodate the "naked" M.2 SSD afterwards, then that's quite possible - that was exactly the purpose why I bought this enclosure! I have been using the free software "Macrium Reflect" and "EaseUs Partition Master" to clone+enlarge my SSDs with the C: partition for some time now - so far it has always worked without any problems. However, it is a good idea to temporarily stick the metal plate supplied onto the SSD (be careful not to produce any short circuits!), because the SSD gets quite hot during cloning.

You have to have an NVMe M.2 interface in your PC, buy such a card, install it in the enclosure and then you can clone your SSD onto it (same size). This is just an enclosure !!!