Hello

No, that's not possible.

At least not without choking. At 32.7cm (specs RTX 2080 Trio MSI) you are at the full HDD cage. If you remove it, you have a full 44cm. I would recommend a maximum of about 30cm with the HDD cage. I now have a GTX 970 in it (28cm).

The R5 case is a HDD monster though. It depends on how many HDDs and SSDs you want to install.

Even if you remove the middle 4 HDD cage, you still have room for 2x2.5" (on the back of the mainboard plate + 3x 3.5" or 2.5" in the lower cage and 2x5.25" mounting bays.

Kind regards Thomas