Yes, if you don't have another Cpu like a Ryzen 3000 series then you have to flash the bios with a Usb stick, which is also possible without a CPU. See Youtube, there are many tutorials about exactly this mobo.
(Bios Flash without CPU)
Otherwise with the older Cpu into the Bios and so the update draufflashen.
Have fun doing it :)
Greetings

Yes, but BIOS update beforehand is necessary

Yes, but you may need to perform a bios update.

https://www.msi.com/Motherboar...