The book "21st Century Learning for 21st Century Skills" presents the refereed proceedings of the 7th European Conference on Technology-Enhanced Learning (EC-TEL 2012), which took place in September 2012 in Saarbrücken, Germany. It includes a carefully curated selection of 26 revised full-text contributions chosen from 130 submitted papers. Additionally, the book contains 12 short contributions, 16 demonstration papers, 11 poster presentations, and an invited paper. The topics covered range from mobile learning and serious games to collaborative learning and learning analytics. This diversity of contributions reflects current trends and challenges in the field of technology-enhanced learning and provides valuable insights into innovative approaches to fostering learning processes.