The book "Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis" offers a comprehensive analysis of mathematical modeling and the associated computational methods that are crucial for understanding the pharmacokinetics and pharmacodynamics of therapeutic drugs. It is aimed at professionals and academics in the fields of drug development and bioengineering, including basic and clinical scientists. The contributions come from leading researchers in the field of pharmacokinetics/pharmacodynamics and highlight the application of these methods in drug development. The book addresses the challenges associated with modeling pharmacokinetic and pharmacodynamic processes and provides insights into the variability of available measurements from laboratory experiments and clinical studies. It is an essential work for anyone involved in the quantification and understanding of the processes of drug absorption, distribution, and action.