The book "Advances in Multiple Sclerosis and Experimental Demyelinating Diseases" offers a comprehensive and innovative analysis of the pathogenesis of Multiple Sclerosis (MS). The authors, led by Dr. Moses Rodriguez, challenge the traditional view that considers the inflammatory process as the primary cause of demyelination. Instead, the role of oligodendrocyte injury is emphasized as a crucial factor in disease development. The work examines various potential causes of MS, including viruses, toxins, and genetic defects, and presents novel approaches to interrupting and reversing demyelination. The authors also discuss the relationship between axonal loss and clinical deficits, as well as the role of CD8+ T cells and perforin. Additionally, innovative methods to promote remyelination in clinical studies based on natural autoantibodies are introduced. The book is aimed at professionals and researchers in the field of neurology and provides valuable insights into the future treatment of MS.