Anticancer Properties of Novel Synthetic Vanillin Derivatives

German, Sedigheh Mehrabian, Zena A. Abdul Hameed Al-Mudaris, Amin Abdul Majid, 2012
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The book "Anticancer Properties of Novel Synthetic Vanillin Derivatives" offers a comprehensive examination of the anticancer properties of novel synthetic vanillin derivatives. The authors, Zena A. Abdul Hameed Al-Mudaris, Amin Abdul Majid, and Sedigheh Mehrabian, analyze the structure-activity relationships of benzyl-o-vanillin and benzimidazole-containing compounds, which are considered important pharmacophores in drug discovery. Cytotoxic analyses demonstrate that these compounds induce apoptosis in leukemic cell lines, indicating their potential use as therapeutic agents against leukemia. The results of DNA binding studies suggest that the interaction with DNA occurs through the groove region, which has significant implications for the development of new cancer drugs. This specialized book is aimed at professionals in oncology and cancer research, providing valuable insights into the utilization of DNA-drug interactions.

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