The book "Antiplasmodial Potentials of Plumeria rubra and Cissampelos mucrona" offers a comprehensive examination of the antimalarial properties of two plants used in traditional medicine. It highlights the ongoing challenges in the fight against malaria and the need to explore new, effective, and cost-efficient treatment options. Through ethnobotanical surveys in Northern Nigeria, the knowledge of traditional healers regarding the treatment of malaria is documented. The study identifies Plumeria rubra and Cissampelos mucronata as promising plants and evaluates their potential to combat the disease. This specialized book is aimed at professionals in the fields of medicine and nursing, as well as those interested in the development of new antimalarial agents.