The textbook "Diagnosis of Catheter Related Blood Stream Infection in ICU Patients" provides a comprehensive analysis of the risks and challenges associated with central venous catheters (CVCs) in intensive care medicine. It highlights the high incidence of catheter-associated bloodstream infections (CRBSI) and their impact on patient safety and healthcare costs. The authors, Rahul Prabhas, Arun Kumar, and V. K. Narang, present findings from studies on catheter colonization rates and the microbial spectrum of CRBSI. By applying quantitative methods to blood cultures and catheter tip cultures, a detailed picture of the infection dynamics is drawn. The book emphasizes the necessity of strict aseptic techniques during catheter placement and maintenance, as well as the importance of regular monitoring and blood cultures for the effective treatment of patients in the ICU.