The guide "Teaching Mono and Di-Hybrid Genetic Crosses in the Classroom" offers an innovative didactic approach to conveying genetic concepts in the classroom. It is aimed at teachers and educators who wish to enhance the understanding of genetic crosses, particularly mono- and di-hybrid crosses. The author, Flor Alba Barrero Ramírez, places special emphasis on considering the prior knowledge of learners to effectively sequence and present the content. By utilizing modern teaching tools, the guide aims to optimize learning about cell division, genetic concepts, and Mendelian laws. This guide is a valuable resource for anyone looking to make the teaching of genetics in schools engaging and comprehensible.