The book "Flow-Induced Changes in Endothelial Cell Micro-Mechanical Properties" by Meron Mengistu provides a comprehensive examination of the mechanical properties of endothelial cells (ECs) and their responses to different flow conditions. It explains how ECs are capable of detecting mechanosensory signals generated by varying shear forces in blood flow. These mechanosensory responses are crucial for understanding the development of atherosclerotic lesions, particularly in areas where blood flow changes. The innovative methodology of oscillating optical tweezers (OOT) is introduced as a tool for analyzing the micro-mechanical properties of ECs. By employing confocal microscopy and the DuolinkTM Proximity Ligation Assay, structural changes near mechanosensors such as integrin and PECAM are visualized, leading to a deeper understanding of the mechanosensitivity of ECs.