The book "The Lennox-Gastaut Syndrome of Unknown Cause" offers a comprehensive analysis of the natural progression of the Lennox-Gastaut syndrome, whose causes remain unknown. It highlights specific aspects of this particular epileptic condition, characterized by distinctive electroclinical features. The authors, Giuseppe Gobbi and Tullio Messana, aim to clarify the relevance of these features for genetic investigations. In an era where modern technologies increasingly enable more precise genetic analyses, this work is particularly significant for professionals engaged in the research and treatment of this complex condition. The book is intended for medical practitioners and caregivers who wish to develop a deeper understanding of the Lennox-Gastaut syndrome and its potential genetic foundations.