The book "Little Known Ways to New Studies on Differentiation of Human Stem Cell" by Kliment Sandjakoski provides a comprehensive analysis of current developments in the differentiation of human stem cells. It highlights the challenges posed by the limitations of experimental techniques and discusses the significance of theoretical paradigms and philosophical concepts in modern molecular biology. The author examines how pre-tolerated cells tend to translocate through the immune system and bypass the reticuloendothelial system. These aspects are crucial for understanding the mechanisms of cell reprogramming, which are essential for maintaining the physiological, molecular, and mechanical properties of stem cells. The book offers valuable insights into the clinical relevance of these topics and their application in various disease states such as inflammation, regeneration, and cancer.