The book "Methods of Assessing the Genotoxicity of Synthetic Bone Substitutes" offers a comprehensive analysis of the genotoxic properties of synthetic bone substitute materials. Over the past two millennia, artificial biomaterials have played a significant role in the treatment of various diseases, with synthetic bone implants increasingly accepted as functional alternatives. Given the potential toxic effects of these materials on the human body, it is crucial to assess their genotoxicity prior to commercialization. The book serves as a reference work that summarizes the principles and methods of various genotoxicity tests, both in vitro and in vivo. It is aimed at researchers who wish to select appropriate tests based on the intended use, type of contact, and duration of implantation.