Micronized carvedilol SR matrix tablet for imporved dissolution

Bappaditya Chatterjee, 2016
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Product details

The book "Micronized Carvedilol SR Matrix Tablet for Improved Dissolution" by Bappaditya Chatterjee provides a comprehensive analysis of the formulation of Carvedilol, a BCS Class II beta-blocker. It explains how the micronization of the active ingredient enhances solubility and promotes systemic absorption. The use of the direct compression method for the production of the matrix tablet is described in detail, with PEO 301 used as a retardant polymer. The optimization of the formulation is carried out through a three-level factorial design that considers the amount of PEO 301 and the hardness of the tablet as dependent variables. The results of the in vitro release studies show that the micronized formulation achieves nearly complete release of the active ingredient within 12 hours, while the non-micronized formulation reaches less than 80%. This specialized book is aimed at professionals and students involved in pharmacology and drug formulation.

Key specifications

Author
Bappaditya Chatterjee
Book cover
Paperback
Year
2016
Item number
55863192

General information

Publisher
Lap Lambert Academic
Category
Reference books
Release date
11.3.2025

Book properties

Author
Bappaditya Chatterjee
Year
2016
Book cover
Paperback
Year
2016

Voluntary climate contribution

CO₂-Emission
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14-day cancellation right
30-day right of return if unopened
24 Months statutory warranty

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