The textbook "MTHFR Gene Polymorphisms and Risk of Male Infertility" offers a comprehensive analysis of the A1298C and C665T polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene and their association with male infertility. It highlights the role of the MTHFR gene in DNA synthesis, folate metabolism, and methylation reactions. The authors, Saima Siddiqi and Noor Ullah, examine the geographical and ethnic distribution of these genetic variants and their potential links to various diseases. Through a detailed exploration of individual SNPs, the book provides a deeper understanding of the biochemical mechanisms that may lead to thermolability and reduced enzymatic activity. This book is aimed at professionals and students in the fields of mathematics and natural sciences who are interested in the genetic influences on health.