The book "Naznachenie depressornyh sinapticheskih processov" by Dzh.S. Sarkisyan offers a comprehensive analysis of the early and late effects of synaptic depression in relation to neurodegenerative diseases such as Parkinson's and Alzheimer's. It examines how spinal structures are affected in Parkinson's disease and the role of long-term memory structures in Alzheimer's disease. The author argues that synaptic depression can be viewed as a protective category that contributes to restoring the original balance between excitatory and inhibitory synaptic processes. This specialized book is aimed at professionals in the fields of medicine and nursing and provides valuable insights into the mechanisms underlying these diseases.