The book "Paroxysmal Nocturnal Hemoglobinuria" offers a comprehensive analysis of this potentially life-threatening condition. It highlights the fundamental insights into the disease as well as the advancements in treatment achieved through the use of the monoclonal antibody Eculizumab. Despite the long-standing knowledge of the PIGA gene, the mechanism of clonal dominance in paroxysmal nocturnal hemoglobinuria remains largely unexplored. This specialized book discusses the direction of ongoing research in this area and the possibility of developing treatment guidelines. It is aimed at basic scientists and medical professionals, particularly immunologists dealing with GPI-anchored proteins and complements, as well as hematologists specializing in bone marrow failure.