The book "Patch Clamp Electrophysiology: Methods and Protocols" offers a comprehensive introduction to the methods and protocols for studying the function of ion channels. It is aimed at both beginners and experienced researchers and covers a variety of standardized and novel methodological approaches. The chapters are structured to guide the reader through the fundamentals of the patch-clamp technique while also introducing more complex, current protocols such as optogenetics. Each chapter includes an introduction to the respective topic, application details, and practical troubleshooting tips to avoid common pitfalls. This book is part of the renowned series "Methods in Molecular Biology" and serves as a valuable reference for current and future ion channel physiologists.