The book "Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances" offers a comprehensive analysis of the three subtypes of peroxisome proliferator-activated receptors (PPARs). These receptors are crucial for regulating numerous physiological and pathophysiological processes. The authors, Mostafa Z. Badr and Jihan A. Youssef, illuminate the discovery history of PPARs and explain their structure as well as post-translational modifications. Additionally, both endogenous and various classes of exogenous ligands are discussed, including subtype-selective, dual, and pan agonists as well as antagonists. The book also describes the tissue distribution and diverse functions of PPAR subtypes in key organs. It is aimed at researchers interested in developing safe and effective PPAR modulators as therapeutic agents for treating a variety of diseases.