The book "Personalized Treatment of Breast Cancer" offers a comprehensive analysis of the key factors that must be considered in personalizing the treatment of primary breast cancer. It addresses topics such as the role of the host, surgical treatment of lymph nodes, radiation therapy, and preoperative systemic treatments that require specialized expertise and multidisciplinary experience. Another focus is on the combination of locoregional treatments with systemic therapies, where genetic factors, such as BRCA mutations, significantly influence treatment options. The book also highlights the latest technological advancements in lymph node diagnostics and mapping, as well as the importance of axillary surgery in patients with nodal metastases. Furthermore, it emphasizes the need for therapy adjustment based on biological tumor characteristics and therapeutic responses. With the introduction of translational research and mathematical prediction tools, such as nomograms, this book provides valuable insights into the individualized care of breast cancer patients and is aimed at professionals and clinical researchers in breast cancer research.