The book "Protein Folding Problem: Intricacies in Unfolding of Plant Proteases" offers a comprehensive analysis of the protein folding process, particularly in the context of plant proteases. It highlights the complex mechanisms that determine how a protein adopts its specific conformation and examines the role of domains in the molecular structure. By choosing Cryptolepain and Heynein as model proteins, the study provides deeper insights into the folding behavior of multi-domain proteins. The research analyzes the intermediates of the folding process and the significance of domain interactions, which are relevant for biotechnology. The findings offer valuable perspectives for understanding protein structure and its applications in biotechnological research.