Psychoneuroimmunology is a specialized book that addresses the rapid development of psychoneuroimmunology (PNI) over the past four decades. This multidisciplinary field provides a scientific foundation for the relationships between mind and body and promotes the development of personalized and systemic medicine. In "Psychoneuroimmunology: Methods and Protocols," experienced researchers share their methods and protocols aimed at developing integrative and individualized therapies, ranging from medications to behaviors. The book is written in the established format of the "Methods in Molecular Biology" series and offers detailed descriptions as well as implementation guidelines that are crucial for achieving optimal results in the laboratory. It supports scientists in pursuing holistic approaches to translate psychoneuroimmunology into improved preventive and personalized medical practice.