The specialized book "Damage and Lifetime of Nickel-Based Alloys under Thermo-Mechanical Fatigue Loading" provides a comprehensive analysis of the behavior of nickel-based alloys under specific loading conditions. The study focuses on the interactions between mechanical strain and temperature, considering various phase positions. A central aspect of the work is the detailed characterization of the microstructures of the alloys, as well as the identification of the damage mechanisms that occur depending on the respective phase positions. Based on these findings, a model is developed to describe the lifetime of the materials, offering valuable insights for applications in engineering and industry. This book is aimed at professionals and students who are engaged with the challenges and research in the field of materials science and engineering.