The book "Synthesis of Ibuprofen Derivatives and Their Biological Application" offers a comprehensive investigation into the synthesis of five therapeutically important ibuprofen derivatives. The research describes a two-step synthesis method that involves the formation of acid chlorides and the conversion of 2-(4-Isobutylphenyl)-Propionyl chloride into active ibuprofen amides. The amide derivatives were synthesized using the established Schotten-Baumann reaction, with thionyl chloride used to form the acid chloride. In the second stage of synthesis, various amines were employed to obtain the corresponding amide derivatives. The resulting compounds were confirmed through melting point determination and FT-IR spectral data. The data obtained demonstrate the successful synthesis of the products, which exhibit enhanced analgesic and anti-inflammatory effects compared to the starting material ibuprofen. This specialized book is aimed at professionals and students in the fields of medicine and pharmacy who are interested in the chemical and biological aspects of ibuprofen and its derivatives.