The textbook "Synthesis of Substituted Butenolides and Related Natural Products" offers a comprehensive investigation into the synthesis and transformation of substituted butenolides, which are found in many natural and unnatural products and exhibit a variety of biological properties. The author, Milandip Karak, presents innovative methods for the stereoselective synthesis of gamma-substituted butenolid derivatives, focusing on the vinylogous aldol reaction of beta-amino-substituted butenolides with aldehydes. This work not only highlights the efficiency and scalability of the proposed methods but also describes the total synthesis of butenolid cores that contain marine natural metabolites, as well as a novel strategy for the reductive dehalogenation of halo-beta-substituted butenolides. The book is aimed at professionals and students in the fields of chemistry and natural sciences who are interested in the synthesis of organic compounds.