The book "Systemic Manifestations of Chronic Obstructive Pulmonary Disease" by Khaled Al-shair offers a comprehensive analysis of the systemic manifestations of chronic obstructive pulmonary disease (COPD). It highlights how factors such as reduced physical performance, muscle wasting, fatigue, and depression significantly contribute to morbidity and mortality in COPD patients. Based on extensive clinical research conducted under the supervision of Prof. Jorgen Vestbo at the University of Manchester, the author presents his findings, which have been recognized at international conferences. The book also includes the Manchester COPD Fatigue Scale, a reliable tool for measuring fatigue in COPD patients. Additionally, it explores a potential link between TNF and the most common comorbidities of COPD, namely depression and fatigue. This work represents a significant contribution to understanding the complex interactions between COPD and its systemic effects.