The splanchnic circulation is a comprehensive monograph that addresses the function of splanchnic circulation in health and disease. It is based on the discussions from the first international symposium on applied physiology of peripheral circulation, titled "Splanchnic Circulation: No Longer a Silent Partner." The individual chapters are roughly aligned with the presentations from the symposium and provide a lasting representation of the concepts and significance developed during this event. Splanchnic circulation is viewed as a dynamic and complex system that plays a crucial role in understanding health and disease. This monograph aims to raise awareness of the importance of splanchnic physiology and to highlight its influence on critical illnesses and the homeostasis of the body's defense mechanisms.