The textbook "Tissue-Protective Cytokines" offers a comprehensive examination of the tissue-protective effects of cytokines, particularly the prototypical tissue-protective cytokine Erythropoietin (EPO). While many cytokines are known for their pro-inflammatory properties, this work highlights the growing interest in the protective effects of certain cytokines. EPO, originally described as neuroprotective, has shown to be beneficial in animal models for ischemic and other types of injuries. The authors, Pietro Ghezzi and Anthony Cerami, present in this book the essential models used to characterize the tissue-protective effects of cytokines. The chapters are written in the established format of the "Methods in Molecular Biology" series and provide a structured approach to the topic, including detailed protocols and helpful tips for avoiding errors. This book is a valuable resource for scientists researching the tissue-protective mechanisms of cytokines.