Xenbase is a comprehensive database for model organisms that focuses on the species Xenopus laevis and Xenopus tropicalis. This database provides valuable informatic resources as well as genomic and biological data that are significant for research in the fields of embryonic development and cell biology. Xenopus is a well-established model organism, distinguished by its robust early embryos and the capability for microinjection and microsurgery. These features make Xenopus a particularly suitable system for conducting experiments to investigate the activity of gene products and to analyze loss-of-function experiments. The database supports researchers in gaining new insights into fundamental biological processes and developing innovative experimental approaches.