The main difference between the Video Doorbell (ZigBee) and the eufy S220 lies in the transmission technology. The Video Doorbell (ZigBee) uses ZigBee for communication, while the eufy S220 uses a different connection technology. Both models have infrared lights for night vision and motion detectors, but the exact details of the Video Doorbell (ZigBee) are not fully available. The eufy S220 offers AI-assisted human detection and WDR technology for better image quality.