Humanity is in great danger as four different plagues threaten the Earth. Players take on the role of highly skilled members of a disease control team to combat this threat. They travel around the world to contain the infection risks while also laying the groundwork for researching cures. Everyone must contribute their unique strengths to defeat the plagues. In this cooperative gaming hit, which was nominated for the Game of the Year award in 2009, all players either win or lose together. Various difficulty levels also maintain long-term gameplay appeal.