In Pyramido: Lost Treasures, you embark on a daring expedition to uncover the wonders hidden deep in the heart of the jungle within lost pyramids. Legends speak of countless precious gemstones concealed within the labyrinthine corridors. Armed with nothing but an improvised map and your unwavering determination, you venture into the dark depths of the pyramids to explore their ever-changing passages and search for the sparkling gems. But be quick, as your competition is also in pursuit of fame and fortune. May the best expedition win!

Players take turns making their moves. On their turn, a player performs four steps in sequence: 1.) Choose a tile and its corresponding gemstone, 2.) If necessary, refill an empty gemstone area, 3.) Reveal a new domino, 4.) Place the domino just picked up. Players progress through four stages. In the first stage, they must place the dominos to create an area of 5x4 or 4x5 blocks.

Their goal is to form the largest possible contiguous color areas from the colored blocks. At the end of a stage, they place colored gemstones on the color areas to activate them. Then, they count how many gemstones are depicted on the blocks of an activated contiguous color area. This gives them their score.

In addition to the colored gemstones, there are also mythical gemstones. These act as wild cards, and two of them can replace one colored gemstone. Unused mythical gemstones grant bonus points at the end of a stage. If a player activates an area with three colored gemstones instead of using a colored gemstone, that area yields double points. The player with the most points after the four stages wins the game.