A pantheon of several civilizations - Greek, Egyptian, and Middle Eastern - is added to 7 Wonder Duel in 7 Wonder Duel: Pantheon, with each god having unique powers to assist you or your opponent.

During Age I, you collect mythological tokens that allow you to choose which deities have a place in the Pantheon. In Age II, you gather tokens of offerings to woo these deities. Then, during Ages II and III, you can activate a god or goddess in the Pantheon instead of taking a map of the pyramid. To do this, you pay the required offerings, and then place the deity next to your city.

With Isis on your side, you can use a card from the discard pile to build one of your Wonders for free. Zeus, whose nod determines what happens, allows you to discard any map of the pyramid as well as any myth or offering token present. The Phoenician goddess Tanit, known for her people's trade, fills your chests with twelve gold coins. Enki, the Sumerian god of craftsmanship, technology, and creation, lets you choose one of the two tokens of progress. Minerva's ability to prevent the conflict pawn from approaching you can help you achieve a military victory or avoid military defeat.

Additionally, instead of adding three guild cards to the game for Age III, you add three of the five Great Temples. Each Great Temple belongs to a different Mediterranean culture, and if you have a mythological token of that culture, you can build the temple for free. These temples are worth a total of 5, 12, or 21 points, depending on the number of points you build.

7 Wonder Duel: Pantheon also includes two new Wonders: the Sanctuary, which provides an extra ride and allows you to summon deities at a reduced price, and the Divine Theatre, which grants points and access to additional gods.