An expert solution for anti-aging night care that provides a lifted, firmer, and more radiant appearance in just one week. This advanced cream, developed with Japanese expertise in neuroscience, has been reformulated to be more effective than ever, visibly stimulating the skin's self-regeneration overnight. Now also refillable. Discover the new, exclusive Shiseido formula. Patented SafflowerRED: Shiseido's advanced research has developed a patented solution that activates the skin's self-regeneration by stimulating its invisible network, helping to target deep wrinkles and sagging. The Mogami flowers, grown in the Yamagata region of Japan, provide high-quality ingredients known for their exceptional skin benefits. Yarrow extract helps to stimulate the skin's nightly repair process, addressing concerns caused by damage sustained during the day. Long-lasting and visible results are guaranteed by ReneuraRED technology.