In The Witch and the Hundred Knight 2, young girls in the region of Kevala suddenly fall ill with a mysterious disease that transforms them into repulsive witches. In the quest to uncover the source of this evil, the Hundred Knight receives active support from the two sisters Amalie and Chelka. Amalie is an agent of an organization that fights against witches, while Chelka is the witch that has awakened in Amalie's younger sister, Milm.

Adaptation to any situation - The player can switch between the 6 facets of the Hundred Knight to turn the battle in their favor. Tochkas, the indispensable servants, can assist in exploration.

Small power package - With Ope Time, damage can be dealt to opponents while replenishing Giga Calories. The third eye can be used for a short time to unleash the full power of the Hundred Knight, gaining increased speed and strength as well as enhanced abilities.

Strength enhancement - At the base, weapons can be forged using the items found. Completing witch missions allows players to acquire Tochkas and other benefits.