This 4GB RAM is 100% compatible with the Shuttle DS81. Help in selecting the right RAM: We offer you faster 1600MHz RAM for your system. Due to the backward compatibility of our RAM to 1333MHz, you can also mix it with existing 1333MHz memory. RAM with ECC provides higher security through error detection and correction. The ECC function is supported if all existing memory is equipped with ECC. You should use UDIMM ECC RAM if existing memory is already equipped with ECC. It is possible to use different RAM sizes in the slots. The Dual Channel Mode is also supported by Intel Flex Memory Technology in this case. When using different RAM capacities, you need to ensure that the memory in Memory Channel A is larger than the memory in Memory Channel B.