Western Digital's M.2 NVMe SSD is compatible with macOS, including "Sequoia" 15.4.1, without the need for additional drivers such as nvmefix.kext. However, to use this SSD in an NVMe enclosure, make sure the enclosure is compatible with NVMe SSDs and has an appropriate M.2 slot. It's also a good idea to add a heatsink if you're using the SSD in an environment where heat could be a problem.