Yes, this SSD physically fits into the Minisforum UM780XTX, as it has the standard M.2 2280 form factor (80 mm x 22 mm x 3.5 mm for 4 TB with heatsink). Compatibility with PCIe 4.0 NVMe is supported by the motherboard, but check the exact placement of the heatsink in the case as Minisforum devices are space limited. If unsure, check the Community for UM780XTX-specific experiences.