The RTX 4060 graphics card generally requires a standard 8-pin PCIe connector, which is compatible with this power supply. However, for a graphics card requiring 450 watts, it is important to check that the power supply can deliver sufficient power via its PCIe connectors. This power supply has several 6+2-pin PCIe connectors, which should be sufficient for a graphics card of this type, but make sure that the total power available for the PCIe components is adequate.