No, the Digital Pen 2 (GX81J19850) is not compatible with the Lenovo Yoga 7 16-inch 2-in-1 according to available product data. The official compatible models are IdeaPad Flex 5 and Lenovo ThinkCentre M75t Gen 2 (11W5). For the Yoga 7 series, it is missing from the list, so consult Lenovo support or the community for confirmation.