USB 3 connections can interfere with Unifying plugs. Solution: Insert the Unifying plug in the USB 2.0 port if available, or distance the plug with a USB 2.0 extension cable. Another possibility is to insert a USB 2.0 memory stick in the adjacent USB port.

I also have Windows 10, so far everything is working fine, the mouse has been in use for 2 years now. My recommendation is to write to Logitech directly and ask for a replacement:)