"Advances in Artificial Intelligence" is a comprehensive collection of expert contributions documenting the results of the 16th Conference of the Spanish Association for Artificial Intelligence (CAEPIA 2015). This conference took place in November 2015 in Albacete, Spain, and attracted numerous submissions from the international research community. Out of 175 submitted papers, 31 revised full texts were selected, addressing various aspects of Artificial Intelligence. The topics range from Bayesian networks and uncertainty modeling to fuzzy logic and soft computing, as well as intelligent systems, machine learning, and social robots. This collection provides valuable insights into current trends and developments in the field of Artificial Intelligence and is an important resource for professionals and students who wish to engage with the latest advancements in this dynamic field.