Overcoming the deep valley! Depression is one of the most common psychiatric disorders. There are many therapeutic options available, and most of them are successful. But what should you do if depression proves to be treatment-resistant, extremely long-lasting, or constantly recurring? Should you just keep trying or seek practical help? The new edition on treatment-resistant depression answers your questions: What are the causes, and how is treatment-resistant depression defined? What other pharmacological and non-pharmacological treatment options are available? What should the overall treatment plan look like? What future perspectives are opening up? Here you will find practical guidelines and recommendations for your therapy plan and benefit from the latest research findings from an international team of authors. This way, you can develop optimal treatment strategies.