This guide includes a comprehensive, clear, and self-contained therapy unit for the structured treatment of patients with alcohol dependence. It has been developed and evaluated for both outpatient and inpatient group therapies, but also offers valuable insights for individual therapeutic work with alcohol-dependent patients. New is the integration of current findings from neurobiology and the resulting implications for psychotherapeutic treatment. The description of the individual therapy modules, along with easily accessible downloadable materials, enables a quick and practical integration of the concept into everyday therapeutic practice.