Applying new technologies, presenting your experience, and thinking of your current practice in the light of new evidence requires an understanding of clinical research methodology. This book is not a textbook, but a brief guide for clinical research practice. It aims to bridge the different points of view of statisticians and clinicians, but does not replace personal meetings and discussions between both professions at the earliest stage of a clinical study. We hope that you find this book enjoyable, easy to read and understand, and helpful for improving your research skills. The editors and authors hope that this book will help you sort and focus your ideas when setting up a clinical study, and understand why certain information should be expressed in specific ways, how data should be compiled, analyzed, and presented. This book is neither exhaustive.