Manufactories from Germany enjoy a worldwide reputation. Whether porcelain, watches, organs, or writing instruments - the craftsmanship finds its roots in the traditional vocational training in Central Europe, which is part of the intangible cultural heritage. However, in the 21st century, the fundamental processes of change brought about by digitalization and globalization are clearly felt by everyone. Manufactories must also reinvent themselves in light of the global market: they are focusing on future technologies and attempting the feat of combining the vision of a "Manufacture 4.0" with the classic self-understanding of workshops. This results in globally connected companies that are oriented towards human scale and are mindful of sustainability in their production. Handmade in Germany provides insight into the practices and future visions of the most important German manufactories.