Starting, shaping, and ending relationships is a central element of the work of (psychiatric) caregivers as well as other health and social professions. The practical handbook by the experienced specialist nurse for psychiatric and psychosomatic care presents relationship care with its elements, influencing factors, and interventions. Significant neurobiological findings relevant to relationship care are highlighted. This practical handbook for nursing practitioners and health and social professions clarifies the biological-neuroscientific, constructivist, social, and psychological attachment theoretical foundations and influencing factors of relationship work and design, describes the history and development of relationship care, and identifies and describes the elements of relationship care, such as attitude, relationship care planning, biographical work, and life event scales.